BDBM50070534 1-(5-Chloro-pyridin-2-yl)-3-[2-(3-ethoxy-2-fluoro-6-methoxy-phenyl)-ethyl]-urea::CHEMBL35729

SMILES CCOc1ccc(OC)c(CCNC(=O)Nc2ccc(Cl)cn2)c1F

InChI Key InChIKey=QCUXORFMMDLGEK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50070534   

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Medivir

Curated by ChEMBL
LigandPNGBDBM50070534(1-(5-Chloro-pyridin-2-yl)-3-[2-(3-ethoxy-2-fluoro-...)
Affinity DataIC50: 8nMAssay Description:Inhibitory effect on wild type HIV- 1 reverse transcriptase using rCdG as template and dGTP as substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Medivir

Curated by ChEMBL
LigandPNGBDBM50070534(1-(5-Chloro-pyridin-2-yl)-3-[2-(3-ethoxy-2-fluoro-...)
Affinity DataIC50: 500nMAssay Description:Inhibitory effect on recombinant HIV- 1 reverse transcriptase which has a mutation Tyr 181 to Cys 181 (clone 90)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Medivir

Curated by ChEMBL
LigandPNGBDBM50070534(1-(5-Chloro-pyridin-2-yl)-3-[2-(3-ethoxy-2-fluoro-...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibitory effect on recombinant HIV- 1 reverse transcriptase which has a mutation Leu 100 to Ile 100 (clone 118)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed