BDBM50070537 1-(5-Chloro-pyridin-2-yl)-3-[2-(2,6-difluoro-phenyl)-ethyl]-urea::CHEMBL36930

SMILES Fc1cccc(F)c1CCNC(=O)Nc1ccc(Cl)cn1

InChI Key InChIKey=ZFYLUXRULKRIDD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50070537   

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Medivir

Curated by ChEMBL
LigandPNGBDBM50070537(1-(5-Chloro-pyridin-2-yl)-3-[2-(2,6-difluoro-pheny...)
Affinity DataIC50: 3nMAssay Description:Compound was tested for its inhibitory effect on wild type HIV- 1 reverse transcriptase using rCdG as template and dGTP as substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Medivir

Curated by ChEMBL
LigandPNGBDBM50070537(1-(5-Chloro-pyridin-2-yl)-3-[2-(2,6-difluoro-pheny...)
Affinity DataIC50: 420nMAssay Description:Compound was tested for its inhibitory effect on recombinant HIV- 1 reverse transcriptase which has a mutation Leu 100 to Ile 100 (clone 118)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Medivir

Curated by ChEMBL
LigandPNGBDBM50070537(1-(5-Chloro-pyridin-2-yl)-3-[2-(2,6-difluoro-pheny...)
Affinity DataIC50: 480nMAssay Description:Compound was tested for its inhibitory effect on recombinant HIV- 1 reverse transcriptase which has a mutation Tyr 181 to Cys 181 (clone 90)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed