BDBM50072378 CHEMBL104193::N-{4-[2-((R)-2-Hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenyl}-4-(3-phenethyl-ureido)-benzenesulfonamide

SMILES O[C@@H](CNCCc1ccc(NS(=O)(=O)c2ccc(NC(=O)NCCc3ccccc3)cc2)cc1)c1cccnc1

InChI Key InChIKey=OQCZSKDYAKSTBO-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50072378   

TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50072378(N-{4-[2-((R)-2-Hydroxy-2-pyridin-3-yl-ethylamino)-...)
Affinity DataEC50:  1.60nMAssay Description:Compound was evaluated for agonistic activity in human Beta-3 adrenergic receptor assay; partial weak agonistMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50072378(N-{4-[2-((R)-2-Hydroxy-2-pyridin-3-yl-ethylamino)-...)
Affinity DataIC50: 160nMAssay Description:Beta-1 adrenergic receptor binding affinity in CHO cells expressing cloned human receptor in the presence of 125 I-iodocyanopindololMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50072378(N-{4-[2-((R)-2-Hydroxy-2-pyridin-3-yl-ethylamino)-...)
Affinity DataIC50: 200nMAssay Description:Beta-2 adrenergic receptor binding affinity in CHO cells expressing cloned human receptor in the presence of 125 I-iodocyanopindololMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed