BDBM50072427 1-(1-(2-(isopropyl(phenyl)amino)-2-oxoethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-3-phenylurea::2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-isopropyl-N-phenyl-acetamide::CHEMBL321761

SMILES CC(C)N(C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2ccccc2)C1=O)c1ccccc1

InChI Key InChIKey=ITMJPTIFWLPIOL-UHFFFAOYSA-N

Data  9 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50072427   

TargetCholecystokinin receptor type A(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072427(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Affinity DataIC50: 50nMAssay Description:Tested for the 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article

TargetGastrin/cholecystokinin type B receptor(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072427(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Affinity DataIC50: 25nMAssay Description:Tested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystok...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article

TargetCholecystokinin receptor type A(Rat)
Neurogen

Curated by ChEMBL
LigandPNGBDBM50072427(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Affinity DataIC50: 250nMAssay Description:Displacement of 125I]-D-Tyr-Gly-[(Nle28,31)CCK-26-33] from rat cell membrane Cholecystokinin type A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072427(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Affinity DataIC50: 55nMAssay Description:Binding affinity against human Cholecystokinin type A receptor in membrane preparation isolated from CHO-K1 cells stably transfected with cDNA of hum...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072427(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Affinity DataIC50: 24nMAssay Description:Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072427(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Affinity DataIC50: 50nMAssay Description:Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type A receptor stably expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072427(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Affinity DataIC50: 25nMAssay Description:Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072427(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Affinity DataIC50: 25nMAssay Description:Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072427(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Affinity DataIC50: 50nMAssay Description:Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetCholecystokinin receptor type A/Gastrin/cholecystokinin type B receptor(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072427(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Affinity DataEC50:  1.60E+3nMAssay Description:Concentration of compound that induced 50% of the maximal contraction in guinea pig gallbladder tissue when tested in vitroMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article