BDBM50072578 (2R,3S)-2-Allyl-N*4*-((S)-1-benzyl-2-oxo-2-phenyl-ethyl)-N*1*-hydroxy-3-isobutyl-succinamide::CHEMBL111104

SMILES CC(C)C[C@H]([C@H](CC=C)C(=O)NO)C(=O)N[C@@H](Cc1ccccc1)C(=O)c1ccccc1

InChI Key InChIKey=AALOSJKQIIRSAO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50072578   

TargetStromelysin-1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50072578((2R,3S)-2-Allyl-N*4*-((S)-1-benzyl-2-oxo-2-phenyl-...)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human recombinant matrix metalloprotease 3 (MMP3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50072578((2R,3S)-2-Allyl-N*4*-((S)-1-benzyl-2-oxo-2-phenyl-...)
Affinity DataIC50: 10nMAssay Description:In vitro inhibitory activity against matrix metalloprotease 1 isolated from the culture medium of human skin fibroblasts induced with PMAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50072578((2R,3S)-2-Allyl-N*4*-((S)-1-benzyl-2-oxo-2-phenyl-...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of matrix metalloprotease 2 (MMP2) of human HT1080 fibrosarcoma cells induced with TNFMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50072578((2R,3S)-2-Allyl-N*4*-((S)-1-benzyl-2-oxo-2-phenyl-...)
Affinity DataIC50: 3.60nMAssay Description:In vitro inhibitory activity against human recombinant matrix metalloprotease 7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed