BDBM50073121 CHEMBL430484::[(S)-6-((S)-2-Mercapto-3-phenyl-propionylamino)-5-oxo-4-aza-spiro[2.6]non-4-yl]-acetic acid

SMILES OC(=O)CN1C(=O)[C@H](CCCC11CC1)NC(=O)[C@@H](S)Cc1ccccc1

InChI Key InChIKey=BEWLTXGGFURBBP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50073121   

TargetAngiotensin-converting enzyme(Rabbit)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50073121([(S)-6-((S)-2-Mercapto-3-phenyl-propionylamino)-5-...)
Affinity DataIC50: 9.60nMAssay Description:In vitro inhibitory activity against Angiotensin I converting enzyme (ACE) isolated from rabbit lung extract using hippuryl-L-histidyl-L-leucine (HHL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Rat)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50073121([(S)-6-((S)-2-Mercapto-3-phenyl-propionylamino)-5-...)
Affinity DataIC50: 377nMAssay Description:In vitro inhibitory activity against purified rat kidney neutral endopeptidase (NEP) using a fluorometric assay with dansyl-Gly-Phe-Arg as the substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed