BDBM50073565 1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-2-(2-methoxy-phenoxy)-ethanone::CHEMBL343283

SMILES COc1ccccc1OCC(=O)N1CCN(CC1)c1nc(N)c2cc(OC)c(OC)cc2n1

InChI Key InChIKey=LPHYFVMMGUVREO-UHFFFAOYSA-N

Data  3 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50073565   

Target5-hydroxytryptamine receptor 2A(Rat)
Recordati

Curated by ChEMBL
LigandPNGBDBM50073565(1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piper...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory concentration against 5-hydroxytryptamine 2A receptor (Inactive at >1000 nM concentration)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Recordati

Curated by ChEMBL
LigandPNGBDBM50073565(1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piper...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory concentration against Dopamine receptor D2 (Inactive at >1000 nM concentration)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Recordati

Curated by ChEMBL
LigandPNGBDBM50073565(1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piper...)
Affinity DataIC50: 170nMAssay Description:Inhibition concentration against 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50073565(1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piper...)
Affinity DataKi:  8.56nMAssay Description:The binding affinity towards Alpha-1B adrenergic receptor in the COS cell line.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Recordati

Curated by ChEMBL
LigandPNGBDBM50073565(1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piper...)
Affinity DataKi:  18.9nMAssay Description:The binding affinity towards Alpha-1A adrenergic receptor in the COS cell line.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50073565(1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piper...)
Affinity DataKi:  18.9nMAssay Description:The binding affinity towards Alpha-1C adrenergic receptor in the COS cell line.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed