BDBM50073573 1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-4-phenyl-butane-1,4-dione::CHEMBL424658

SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)CCC(=O)c1ccccc1

InChI Key InChIKey=FTDBTBLFOYBMNU-UHFFFAOYSA-N

Data  3 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50073573   

Target5-hydroxytryptamine receptor 2A(Rat)
Recordati

Curated by ChEMBL
LigandPNGBDBM50073573(1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piper...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory concentration against 5-hydroxytryptamine 2A receptor (Inactive at >1000 nM concentration)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Recordati

Curated by ChEMBL
LigandPNGBDBM50073573(1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piper...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory concentration against Dopamine receptor D2 (Inactive at >1000 nM concentration)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Recordati

Curated by ChEMBL
LigandPNGBDBM50073573(1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piper...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory concentration against 5-hydroxytryptamine 1A receptor (Inactive at >1000 nM concentration)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50073573(1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piper...)
Affinity DataKi:  4.43nMAssay Description:The binding affinity towards Alpha-1B adrenergic receptor in the COS cell line.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Recordati

Curated by ChEMBL
LigandPNGBDBM50073573(1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piper...)
Affinity DataKi:  5.68nMAssay Description:The binding affinity towards Alpha-1A adrenergic receptor in the COS cell line.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50073573(1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piper...)
Affinity DataKi:  19.4nMAssay Description:The binding affinity towards Alpha-1C adrenergic receptor in the COS cell line.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed