BDBM50073760 3-[2-(2-Amino-ethylamino)-9-ethyl-9H-purin-6-ylamino]-benzonitrile; hydrochloride::CHEMBL175158::CHEMBL557975

SMILES CCn1cnc2c(Nc3cccc(c3)C#N)nc(NCCN)nc12

InChI Key InChIKey=POPOWOGWYKGXQA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50073760   

TargetProtein kinase C alpha type(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073760(CHEMBL175158 | 3-[2-(2-Amino-ethylamino)-9-ethyl-9...)
Affinity DataIC50: 7.80E+4nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073760(CHEMBL175158 | 3-[2-(2-Amino-ethylamino)-9-ethyl-9...)
Affinity DataIC50: 560nMAssay Description:Inhibition of Cyclin-dependent kinase 1, CDK1-related human bladder carcinoma (T24) cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha/beta/gamma(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073760(CHEMBL175158 | 3-[2-(2-Amino-ethylamino)-9-ethyl-9...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of Protein kinase AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073760(CHEMBL175158 | 3-[2-(2-Amino-ethylamino)-9-ethyl-9...)
Affinity DataIC50: 560nMAssay Description:Inhibitory activity against cyclin-dependent kinase 1 (CDK1) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073760(CHEMBL175158 | 3-[2-(2-Amino-ethylamino)-9-ethyl-9...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibit of epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed