BDBM50074060 CHEMBL3409869::US9242970, 127

SMILES COc1cccc(OC)c1C1CCC(=O)N1Cc1ccc2oc3ccccc3c2c1

InChI Key InChIKey=FHPANOIZEGWXAC-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50074060   

TargetOrexin receptor type 2(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM50074060(CHEMBL3409869 | US9242970, 127)
Affinity DataIC50: 20nMT: 2°CAssay Description:In Vitro Assay: Intracellular Calcium Measurements:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details
Go to US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM50074060(CHEMBL3409869 | US9242970, 127)
Affinity DataIC50: 14nMT: 2°CAssay Description:In Vitro Assay: Intracellular Calcium Measurements:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details
Go to US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM50074060(CHEMBL3409869 | US9242970, 127)
Affinity DataIC50: 14nMAssay Description:Antagonist activity at human orexin 2 receptor expressed in CHO cells assessed as inhibition of orexin-A-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM50074060(CHEMBL3409869 | US9242970, 127)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at human orexin 1 receptor expressed in CHO cells assessed as inhibition of orexin-A-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50074060(CHEMBL3409869 | US9242970, 127)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using testosterone as marker substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMed