BDBM50074600 CHEMBL358368::[3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2-ylmethyl]-dimethyl-amine

SMILES CN(C)CC1C2CCC(CC2)C1c1ccc(Cl)c(Cl)c1

InChI Key InChIKey=JOQQHMGSIKNGAF-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50074600   

TargetSodium-dependent dopamine transporter(Rat)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50074600([3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2-ylmet...)
Affinity DataIC50: 14nMAssay Description:Inhibitory potency against dopamine (DA) transporter using [3H]WIN-35428 (WIN-) binding assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50074600([3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2-ylmet...)
Affinity DataIC50: 14.2nMAssay Description:Inhibitory binding activity against rat striatal tissue using [3H]WIN-35248 as the radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50074600([3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2-ylmet...)
Affinity DataIC50: 14.2nMAssay Description:Inhibitory binding activity against rat striatal tissue using [3H]WIN-35248 as the radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50074600([3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2-ylmet...)
Affinity DataIC50: 29nMAssay Description:Inhibitory potency against [3H]DA uptake using [3H]WIN-35428 (WIN-) binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50074600([3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2-ylmet...)
Affinity DataIC50: 29.3nMAssay Description:Inhibition of dopamine uptake into rat striatal tissue, using [3H]- dopamine as the radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50074600([3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2-ylmet...)
Affinity DataIC50: 29.3nMAssay Description:Inhibition of dopamine uptake into rat striatal tissue, using [3H]- dopamine as the radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50074600([3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2-ylmet...)
Affinity DataIC50: 96nMAssay Description:Selectivity for the norepinephrine transporter using [3H]nisoxetine binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50074600([3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2-ylmet...)
Affinity DataIC50: 261nMAssay Description:Selectivity for the Serotonin transporter using [3H]paroxetine binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2012
Entry Details Article
PubMed