BDBM50075312 (Difluoro-naphthalen-2-yl-methyl)-phosphonic acid::CHEMBL60857::difluoro(2-naphthyl)methylphosphonate::difluoro(naphthalen-2-yl)methylphosphonate

SMILES OP(O)(=O)C(F)(F)c1ccc2ccccc2c1

InChI Key InChIKey=XJGUKDJAOUXADK-UHFFFAOYSA-N

Data  3 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50075312   

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Tokyo University of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50075312(difluoro(2-naphthyl)methylphosphonate | difluoro(n...)
Affinity DataIC50: 7.18E+5nMAssay Description:Inhibitory potency for the protein tyrosine phosphatase (PTP 1B)-catalyzed hydrolysis of p-nitrophenol phosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase C(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50075312(difluoro(2-naphthyl)methylphosphonate | difluoro(n...)
Affinity DataIC50: 1.00E+6nMAssay Description:Compound was evaluated for 50% inhibition of CD45 using uM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Tokyo University of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50075312(difluoro(2-naphthyl)methylphosphonate | difluoro(n...)
Affinity DataIC50: 9.50E+4nMAssay Description:Compound was evaluated for 50% inhibition of PTP1B using uM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Tokyo University of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50075312(difluoro(2-naphthyl)methylphosphonate | difluoro(n...)
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of human PTP1B expressed in Escherichia coli BL21(DE3) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Tokyo University of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50075312(difluoro(2-naphthyl)methylphosphonate | difluoro(n...)
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Tokyo University of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50075312(difluoro(2-naphthyl)methylphosphonate | difluoro(n...)
Affinity DataKi:  1.97E+5nMAssay Description:Compound was evaluated for 50% inhibition of PTP1B using uM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Tokyo University of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50075312(difluoro(2-naphthyl)methylphosphonate | difluoro(n...)
Affinity DataKi:  1.79E+5nMAssay Description:Inhibitory activity against Yersinia Protein-tyrosine phosphatase 1BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Tokyo University of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50075312(difluoro(2-naphthyl)methylphosphonate | difluoro(n...)
Affinity DataKi:  1.79E+5nMAssay Description:Binding affinity towards recombinant human Protein-tyrosine phosphatase 1B was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed