BDBM50075577 CHEMBL3415556

SMILES CCN(C)S(=O)(=O)Nc1cc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c(F)c1

InChI Key InChIKey=LLAFAUCUKNMECC-UHFFFAOYSA-N

Data  2 IC50  2 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50075577   

TargetSerine/threonine-protein kinase B-raf(Human)
Umr Cnrs-Universit£

Curated by ChEMBL
LigandPNGBDBM50075577(CHEMBL3415556)
Affinity DataIC50: 100nMAssay Description:Inhibition of B-Raf V600E mutant (unknown origin) assessed as inhibition of phosphorylation of peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Umr Cnrs-Universit£

Curated by ChEMBL
LigandPNGBDBM50075577(CHEMBL3415556)
Affinity DataKd:  690nMAssay Description:Binding affinity to wild type B-Raf (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Umr Cnrs-Universit£

Curated by ChEMBL
LigandPNGBDBM50075577(CHEMBL3415556)
Affinity DataEC50: >1.00E+4nMAssay Description:Activation of tumorigenic wild type B-Raf in human IPC-298 cells with Ras mutation assessed as phosphorylation of ERKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Umr Cnrs-Universit£

Curated by ChEMBL
LigandPNGBDBM50075577(CHEMBL3415556)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of B-Raf V600E mutant in human A375 cells assessed as phosphorylation of ERKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Umr Cnrs-Universit£

Curated by ChEMBL
LigandPNGBDBM50075577(CHEMBL3415556)
Affinity DataKd:  1.41E+3nMAssay Description:Binding affinity to B-Raf V600E mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed