BDBM50076429 4-Fluoro-N-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-3-methyl-N-pyridin-2-yl-benzamide::CHEMBL1910243::CHEMBL43297

SMILES COc1ccccc1N1CCN(CCN(C(=O)c2ccc(F)c(C)c2)c2ccccn2)CC1

InChI Key InChIKey=MWCWNEWLVWIYOH-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50076429   

Target5-hydroxytryptamine receptor 1A(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50076429(CHEMBL1910243 | CHEMBL43297 | 4-Fluoro-N-{2-[4-(2-...)
Affinity DataKi:  0.791nMAssay Description:In vitro inhibition of [3H]- 8-OH-DPAT binding to cloned cell line containing human 5-hydroxytryptamine 1A receptor (Experiment 2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50076429(CHEMBL1910243 | CHEMBL43297 | 4-Fluoro-N-{2-[4-(2-...)
Affinity DataKi:  1.10nMAssay Description:In vitro inhibition of [3H]- 8-OH-DPAT binding to cloned cell line containing human 5-hydroxytryptamine 1A receptor (Experiment 2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Mouse)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50076429(CHEMBL1910243 | CHEMBL43297 | 4-Fluoro-N-{2-[4-(2-...)
Affinity DataKi:  2.90nMAssay Description:Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, binding (Experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50076429(CHEMBL1910243 | CHEMBL43297 | 4-Fluoro-N-{2-[4-(2-...)
Affinity DataKi:  4nMAssay Description:In vitro inhibition of [3H]- 8-OH-DPAT binding to cloned cell line containing human 5-hydroxytryptamine 1A receptor (Experiment 1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Mouse)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50076429(CHEMBL1910243 | CHEMBL43297 | 4-Fluoro-N-{2-[4-(2-...)
Affinity DataKi:  4nMAssay Description:Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50076429(CHEMBL1910243 | CHEMBL43297 | 4-Fluoro-N-{2-[4-(2-...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]-8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50076429(CHEMBL1910243 | CHEMBL43297 | 4-Fluoro-N-{2-[4-(2-...)
Affinity DataKi:  13nMAssay Description:Binding affinity to alpha 1A adrenergic receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50076429(CHEMBL1910243 | CHEMBL43297 | 4-Fluoro-N-{2-[4-(2-...)
Affinity DataKi:  13.2nMAssay Description:Binding affinity to alpha1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed