BDBM50078606 CHEMBL3415154

SMILES Cc1nnc2CCc3cc(c(F)cc3-n12)-c1cccnc1

InChI Key InChIKey=IBUSVQUTXJGYEA-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50078606   

TargetCytochrome P450 11B2, mitochondrial(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50078606(CHEMBL3415154)
Affinity DataIC50: 131nMAssay Description:Inhibition of CYP11B2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50078606(CHEMBL3415154)
Affinity DataIC50: 131nMAssay Description:Inhibition of human CYP11B2 expressed in V79 MZh cells using [14C]-deoxycorticosterone substrate incubated for 6 hrs by HPTLC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Saarland University and Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM50078606(CHEMBL3415154)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP17 expressed in Escherichia coli coexpressing human CYP17 and NADPH-P450 reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetAromatase(Human)
Saarland University and Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM50078606(CHEMBL3415154)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP19 in human placental microsomes using [1beta-3H]androstenedione substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50078606(CHEMBL3415154)
Affinity DataIC50: 1.26E+4nMAssay Description:Inhibition of CYP11B1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50078606(CHEMBL3415154)
Affinity DataIC50: 1.26E+4nMAssay Description:Inhibition of human CYP11B1 expressed in V79 MZh cells using [14C]-deoxycorticosterone substrate incubated for 6 hrs by HPTLC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed