BDBM50078827 2-(pyridin-3-yl)-1H-benzo[d]imidazole::2-Pyridin-3-yl-1H-benzoimidazole::CHEMBL83103::LDHA Inhibitor, 10

SMILES c1ccc2[nH]c(nc2c1)-c1cccnc1

InChI Key InChIKey=BOUOQESVDURNSB-UHFFFAOYSA-N

Data  4 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50078827   

TargetL-lactate dehydrogenase A chain(Rat)
Astrazeneca

LigandPNGBDBM50078827(CHEMBL83103 | LDHA Inhibitor, 10 | 2-Pyridin-3-yl-...)
Affinity DataKd:  1.40E+6nMpH: 7.5Assay Description:NMR spectra were acquired on Bruker Avance 600 MHz spectrometers at 298 K using a 5 mm triple-resonance HCN cryoprobe. Ligand binding was detected u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2012
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Rat)
Astrazeneca

LigandPNGBDBM50078827(CHEMBL83103 | LDHA Inhibitor, 10 | 2-Pyridin-3-yl-...)
Affinity DataIC50: 5.00E+5nMpH: 7.5 T: 2°CAssay Description:Enzyme assay using lactate dehydrogenase A (LDHA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50078827(CHEMBL83103 | LDHA Inhibitor, 10 | 2-Pyridin-3-yl-...)
Affinity DataKd:  4.10E+5nMAssay Description:Dissociation constant when binding to FK506 binding protein (FKBP).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMethionine aminopeptidase(Escherichia coli (strain K12))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50078827(CHEMBL83103 | LDHA Inhibitor, 10 | 2-Pyridin-3-yl-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Co2+ loaded MetAP expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Goethe University

Curated by ChEMBL
LigandPNGBDBM50078827(CHEMBL83103 | LDHA Inhibitor, 10 | 2-Pyridin-3-yl-...)
Affinity DataIC50: 9.10E+4nMAssay Description:Inhibition of recombinant soluble epoxide hydrolase (unknown origin) using PHOME as substrate incubated 15 mins prior to substrate addition measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetCytochrome P450 2B1(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50078827(CHEMBL83103 | LDHA Inhibitor, 10 | 2-Pyridin-3-yl-...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibitory potency to aminopyrine N-demethylase activity (P450) in hepatic microsomes from phenobarbitone-induced rats.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed