BDBM50079080 1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-[1-(2-morpholin-4-yl-2-oxo-ethyl)-piperidin-4-yl]-ethanone::CHEMBL328713

SMILES Clc1cc(Br)c2[C@@H](C3CCN(CC3)C(=O)CC3CCN(CC(=O)N4CCOCC4)CC3)c3ncc(Br)cc3CCc2c1

InChI Key InChIKey=YCRWTAAJDYJPGL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50079080   

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079080(1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of [3H]FPP incorporation into His6-H-Ras-CVLS by farnesyl transferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079080(1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...)
Affinity DataIC50: 25nMAssay Description:Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed