BDBM50080562 4-(2-Benzhydryloxy-ethyl)-1-(3-phenyl-propyl)-piperazin-2-one::CHEMBL124222

SMILES O=C1CN(CCOC(c2ccccc2)c2ccccc2)CCN1CCCc1ccccc1

InChI Key InChIKey=KSRAFZQYEJWAQE-UHFFFAOYSA-N

Data  3 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50080562   

TargetSodium-dependent dopamine transporter(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50080562(4-(2-Benzhydryloxy-ethyl)-1-(3-phenyl-propyl)-pipe...)
Affinity DataIC50: 10nMAssay Description:Inhibition of [3H]DA uptake in HEK cells expressing dopamine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50080562(4-(2-Benzhydryloxy-ethyl)-1-(3-phenyl-propyl)-pipe...)
Affinity DataIC50: 10nMAssay Description:Inhibition of [3H]- 5-HT uptake in HEK cells expressing serotonin transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50080562(4-(2-Benzhydryloxy-ethyl)-1-(3-phenyl-propyl)-pipe...)
Affinity DataIC50: 10nMAssay Description:Inhibition of [3H]- NE uptake in HEK cells expressing norepinephrine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50080562(4-(2-Benzhydryloxy-ethyl)-1-(3-phenyl-propyl)-pipe...)
Affinity DataKi:  5.85E+3nMAssay Description:Compound was tested for its affinity by the inhibition of [125I]RTI-55 binding at norepinephrine transporter (NET) transfected in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50080562(4-(2-Benzhydryloxy-ethyl)-1-(3-phenyl-propyl)-pipe...)
Affinity DataKi:  5.90E+3nMAssay Description:Inhibition of [125I]RTI-55 binding to serotonin transporter (SERT) expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50080562(4-(2-Benzhydryloxy-ethyl)-1-(3-phenyl-propyl)-pipe...)
Affinity DataKi:  8.20E+3nMAssay Description:Inhibition of [125I]RTI-55 binding at Dopamine transporter (DAT) expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed