BDBM50080571 CHEMBL123830::N-(2-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethylamino}-ethyl)-2-(4-fluoro-phenyl)-acetamide

SMILES Fc1ccc(CC(=O)NCCNCCOC(c2ccc(F)cc2)c2ccc(F)cc2)cc1

InChI Key InChIKey=AWHFBFFVXKIBQI-UHFFFAOYSA-N

Data  3 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50080571   

TargetSodium-dependent dopamine transporter(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50080571(N-(2-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethylamino...)
Affinity DataIC50: 47nMAssay Description:Inhibition of [3H]DA uptake in HEK cells expressing dopamine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50080571(N-(2-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethylamino...)
Affinity DataKi:  54nMAssay Description:Inhibition of [125I]RTI-55 binding at Dopamine transporter (DAT) expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50080571(N-(2-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethylamino...)
Affinity DataIC50: 299nMAssay Description:Inhibition of [3H]- NE uptake in HEK cells expressing norepinephrine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50080571(N-(2-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethylamino...)
Affinity DataKi:  351nMAssay Description:Inhibition of [125I]RTI-55 binding to serotonin transporter (SERT) expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50080571(N-(2-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethylamino...)
Affinity DataKi:  844nMAssay Description:Inhibition of [125I]RTI-55 binding to norepinephrine transporter (NET) expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50080571(N-(2-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethylamino...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of [3H]- 5-HT uptake in HEK cells expressing serotonin transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed