BDBM50081148 7-Chloro-3-(3,5-dimethyl-phenyl)-6-nitro-4-((S)-2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one::CHEMBL294910::CHEMBL90725

SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(c(Cl)cc2[n-]c1=[OH+])[N+]([O-])=O

InChI Key InChIKey=IXZTVVBIBRTWRH-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50081148   

TargetGonadotropin-releasing hormone receptor(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50081148(CHEMBL294910 | CHEMBL90725 | 7-Chloro-3-(3,5-dimet...)
Affinity DataIC50: 10nMAssay Description:Binding affinity for Gonadotropin-releasing hormone receptor in rat pituitary membrane at 10 buserelin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50081148(CHEMBL294910 | CHEMBL90725 | 7-Chloro-3-(3,5-dimet...)
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration against binding of rat Gonadotropin-releasing hormone receptor using [125I]buserelinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50081148(CHEMBL294910 | CHEMBL90725 | 7-Chloro-3-(3,5-dimet...)
Affinity DataIC50: 10nMAssay Description:Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50081148(CHEMBL294910 | CHEMBL90725 | 7-Chloro-3-(3,5-dimet...)
Affinity DataIC50: 150nMAssay Description:Binding affinity for Gonadotropin-releasing hormone receptor in rat pituitary membrane at 10 buserelin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50081148(CHEMBL294910 | CHEMBL90725 | 7-Chloro-3-(3,5-dimet...)
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration against binding of rat Gonadotropin-releasing hormone receptor using [125I]buserelinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed