BDBM500817 7-[[5-[(2R)-2-[(3- fluoroazetidin- 1-yl)methyl]mor pholin-4-yl]-2- pyridyl]amino] 4-(7-fluoroimidazo [1,2-a]pyridin- 3-yl)isoindolin- 1-one::US11021481, Compound I-482::US11078201, Compound I-482::US11548890, Compound I-482

SMILES FC1CN(C[C@@H]2CN(CCO2)c2ccc(Nc3ccc(c4CNC(=O)c34)-c3cnc4cc(F)ccn34)nc2)C1

InChI Key InChIKey=IQWKUBQGMVYDMO-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 500817   

LigandPNGBDBM500817(7-[[5-[(2R)-2-[(3- fluoroazetidin- 1-yl)methyl]mor...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent

LigandPNGBDBM500817(7-[[5-[(2R)-2-[(3- fluoroazetidin- 1-yl)methyl]mor...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500817(7-[[5-[(2R)-2-[(3- fluoroazetidin- 1-yl)methyl]mor...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

LigandPNGBDBM500817(7-[[5-[(2R)-2-[(3- fluoroazetidin- 1-yl)methyl]mor...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500817(7-[[5-[(2R)-2-[(3- fluoroazetidin- 1-yl)methyl]mor...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent