BDBM500818 4-(8- fluoroimidazo [1,2-a]pyridin- 3-yl)-7-[[5- [(2S)-2-(1- hydroxy-1-methyl- ethyl)morpholin- 4-yl]-2- pyridyl]amino]- 2,3-dihydropyrrolo [3,4-c]pyridin- 1-one::US11021481, Compound I-483::US11078201, Compound I-483::US11548890, Compound I-483

SMILES CC(C)(O)[C@@H]1CN(CCO1)c1ccc(Nc2cnc(c3CNC(=O)c23)-c2cnc3c(F)cccn23)nc1

InChI Key InChIKey=DICYWKLACKPXBE-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 500818   

LigandPNGBDBM500818(4-(8- fluoroimidazo [1,2-a]pyridin- 3-yl)-7-[[5- [...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

LigandPNGBDBM500818(4-(8- fluoroimidazo [1,2-a]pyridin- 3-yl)-7-[[5- [...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500818(4-(8- fluoroimidazo [1,2-a]pyridin- 3-yl)-7-[[5- [...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

LigandPNGBDBM500818(4-(8- fluoroimidazo [1,2-a]pyridin- 3-yl)-7-[[5- [...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent

LigandPNGBDBM500818(4-(8- fluoroimidazo [1,2-a]pyridin- 3-yl)-7-[[5- [...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent