BDBM500822 4-(8-fluoro-7- methyl-imidazo[1,2- a]pyridin-3-yl)- 7-[[5-[(2R)-2-(1- hydroxy-1-methyl- ethyl)morpholin- 4-yl]-2-pyridyl] amino]isoindolin-1- one::US11021481, Compound I-487::US11078201, Compound I-487::US11548890, Compound I-487

SMILES Cc1ccn2c(cnc2c1F)-c1ccc(Nc2ccc(cn2)N2CCO[C@H](C2)C(C)(C)O)c2C(=O)NCc12

InChI Key InChIKey=MSNLMAFETKLEGD-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 500822   

LigandPNGBDBM500822(4-(8-fluoro-7- methyl-imidazo[1,2- a]pyridin-3-yl)...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

LigandPNGBDBM500822(4-(8-fluoro-7- methyl-imidazo[1,2- a]pyridin-3-yl)...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

LigandPNGBDBM500822(4-(8-fluoro-7- methyl-imidazo[1,2- a]pyridin-3-yl)...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500822(4-(8-fluoro-7- methyl-imidazo[1,2- a]pyridin-3-yl)...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent

LigandPNGBDBM500822(4-(8-fluoro-7- methyl-imidazo[1,2- a]pyridin-3-yl)...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent