BDBM50082344 3-(3-Fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-5,5-dimethyl-5H-furan-2-one::CHEMBL321217

SMILES CC1(C)OC(=O)C(=C1c1ccc(cc1)S(C)(=O)=O)c1cccc(F)c1

InChI Key InChIKey=NXERGIJHYVUXHM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50082344   

TargetProstaglandin G/H synthase 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082344(3-(3-Fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-5...)
Affinity DataIC50: 40nMAssay Description:In vitro inhibitory potency against human COX-2 (HWB COX-2) by whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082344(3-(3-Fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-5...)
Affinity DataIC50: 300nMAssay Description:In vitro inhibitory potency against human COX-2 (HWB COX-2) by whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082344(3-(3-Fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-5...)
Affinity DataIC50: 1.40E+4nMAssay Description:In vitro inhibitory potency against U-937 microsomal COX-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082344(3-(3-Fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-5...)
Affinity DataIC50: 7.00E+4nMAssay Description:In vitro inhibitory potency against human COX-1 in stably transfected chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed