BDBM50082349 3-(3-Fluoro-phenoxy)-4-(4-methanesulfonyl-phenyl)-5,5-dimethyl-5H-furan-2-one::CHEMBL322132

SMILES CC1(C)OC(=O)C(Oc2cccc(F)c2)=C1c1ccc(cc1)S(C)(=O)=O

InChI Key InChIKey=NSOLEUGGZJTHNS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50082349   

TargetProstaglandin G/H synthase 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082349(3-(3-Fluoro-phenoxy)-4-(4-methanesulfonyl-phenyl)-...)
Affinity DataIC50: 20nMAssay Description:In vitro inhibitory potency against human COX-2 (HWB COX-2) by whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082349(3-(3-Fluoro-phenoxy)-4-(4-methanesulfonyl-phenyl)-...)
Affinity DataIC50: 70nMAssay Description:In vitro inhibitory potency against human COX-2 (HWB COX-2) by whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082349(3-(3-Fluoro-phenoxy)-4-(4-methanesulfonyl-phenyl)-...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibitory potency against U-937 microsomal COX-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082349(3-(3-Fluoro-phenoxy)-4-(4-methanesulfonyl-phenyl)-...)
Affinity DataIC50: 2.31E+4nMAssay Description:In vitro inhibitory potency against human COX-1 in stably transfected chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed