BDBM50082360 3-(Isoquinolin-5-yloxy)-4-(4-methanesulfonyl-phenyl)-5,5-dimethyl-5H-furan-2-one::CHEMBL323267

SMILES CC1(C)OC(=O)C(Oc2cccc3cnccc23)=C1c1ccc(cc1)S(C)(=O)=O

InChI Key InChIKey=PRVRFYFBPULTKN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50082360   

TargetProstaglandin G/H synthase 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082360(3-(Isoquinolin-5-yloxy)-4-(4-methanesulfonyl-pheny...)
Affinity DataIC50: 260nMAssay Description:Inhibitory potency against PGE-2 production in the human whole blood (HWB COX-2) assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082360(3-(Isoquinolin-5-yloxy)-4-(4-methanesulfonyl-pheny...)
Affinity DataIC50: 670nMAssay Description:Inhibition of PGE-2 production in CHO cells expressing human COX-2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082360(3-(Isoquinolin-5-yloxy)-4-(4-methanesulfonyl-pheny...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of COX-1 in U-937 (human lymphoma) cell microsomes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed