BDBM500824 7-[[5-[(2S)-2- (1-hydroxy-1- methylethyl)morpholin- 4-yl]-2-pyripyl]amino]- 4-(6-methylpyrazo- lo[1,5-a]pyridin-3- yl)isoindolin- 1-one::US11021481, Compound I-489::US11078201, Compound I-489::US11548890, Compound I-489

SMILES Cc1ccc2c(cnn2c1)-c1ccc(Nc2ccc(cn2)N2CCO[C@@H](C2)C(C)(C)O)c2C(=O)NCc12

InChI Key InChIKey=XWSTWJWLGQPFLJ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 500824   

LigandPNGBDBM500824(7-[[5-[(2S)-2- (1-hydroxy-1- methylethyl)morpholin...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500824(7-[[5-[(2S)-2- (1-hydroxy-1- methylethyl)morpholin...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

LigandPNGBDBM500824(7-[[5-[(2S)-2- (1-hydroxy-1- methylethyl)morpholin...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent

LigandPNGBDBM500824(7-[[5-[(2S)-2- (1-hydroxy-1- methylethyl)morpholin...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

LigandPNGBDBM500824(7-[[5-[(2S)-2- (1-hydroxy-1- methylethyl)morpholin...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent