BDBM50082555 4-(4-Methoxy-benzenesulfonyl)-thiomorpholine-3-carboxylic acid hydroxyamide::CHEMBL345054

SMILES COc1ccc(cc1)S(=O)(=O)N1CCSCC1C(=O)NO

InChI Key InChIKey=SKVZRQFKXKDXCW-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50082555   

TargetStromelysin-1(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082555(4-(4-Methoxy-benzenesulfonyl)-thiomorpholine-3-car...)
Affinity DataIC50: 15nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-3.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082555(4-(4-Methoxy-benzenesulfonyl)-thiomorpholine-3-car...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibitory activity against collagenase-3 (matrix metalloprotease-13).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetMatrilysin(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082555(4-(4-Methoxy-benzenesulfonyl)-thiomorpholine-3-car...)
Affinity DataIC50: 2.07E+3nMAssay Description:In vitro inhibitory activity against matrilysin (matrix metalloprotease-7).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082555(4-(4-Methoxy-benzenesulfonyl)-thiomorpholine-3-car...)
Affinity DataIC50: 62nMAssay Description:In vitro inhibitory activity against truncated collagenase-1 (matrix metalloprotease-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetMatrilysin(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082555(4-(4-Methoxy-benzenesulfonyl)-thiomorpholine-3-car...)
Affinity DataIC50: 2.03E+3nMAssay Description:Inhibition of MMP7 (unknown origin) expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate after 20 to 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082555(4-(4-Methoxy-benzenesulfonyl)-thiomorpholine-3-car...)
Affinity DataIC50: 62nMAssay Description:Inhibition of human interstitial recombinant N-terminal MMP1 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082555(4-(4-Methoxy-benzenesulfonyl)-thiomorpholine-3-car...)
Affinity DataIC50: 1nMAssay Description:Inhibition of MMP13 (unknown origin) expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate after 20 to 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082555(4-(4-Methoxy-benzenesulfonyl)-thiomorpholine-3-car...)
Affinity DataIC50: 15nMAssay Description:Inhibition of truncated human recombinant MMP3 catalytic domain expressed in Escherichia coli BL21(DE3) after 3 hrs in presence of [H]-transferrinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed