BDBM50082565 (S)-4-(4'-Fluoro-biphenyl-4-sulfonyl)-2,2-dimethyl-[1,4]thiazepane-3-carboxylic acid hydroxyamide::CHEMBL344634

SMILES CC1(C)SCCCN([C@H]1C(=O)NO)S(=O)(=O)c1ccc(cc1)-c1ccc(F)cc1

InChI Key InChIKey=VCUJZXCWHYPIIH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50082565   

Target72 kDa type IV collagenase(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082565((S)-4-(4'-Fluoro-biphenyl-4-sulfonyl)-2,2-dimethyl...)
Affinity DataIC50: 1.30nMAssay Description:In vitro inhibitory activity against gelatinase-A (matrix metalloprotease-2).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082565((S)-4-(4'-Fluoro-biphenyl-4-sulfonyl)-2,2-dimethyl...)
Affinity DataIC50: 2.90nMAssay Description:In vitro inhibitory activity against truncated collagenase-1 (matrix metalloprotease-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082565((S)-4-(4'-Fluoro-biphenyl-4-sulfonyl)-2,2-dimethyl...)
Affinity DataIC50: 6.5nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-3.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed