BDBM500828 7-[[6- (3,3a,4,5,6,6a- hexahydro- 2]H-pyrrolo[2,3- c]pyrrol-1-yl)- 2-pyridyl]amino]- 4-(7-fluoroimidazo [1,2-a]pyridin-3- yl)isoindolin- 1-one::US11021481, Compound I-493::US11078201, Compound I-493::US11548890, Compound I-493

SMILES Fc1ccn2c(cnc2c1)-c1ccc(Nc2cccc(n2)N2CCC3CNCC23)c2C(=O)NCc12

InChI Key InChIKey=PAKVDYFGTCCCFC-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 500828   

LigandPNGBDBM500828(7-[[6- (3,3a,4,5,6,6a- hexahydro- 2]H-pyrrolo[2,3-...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500828(7-[[6- (3,3a,4,5,6,6a- hexahydro- 2]H-pyrrolo[2,3-...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500828(7-[[6- (3,3a,4,5,6,6a- hexahydro- 2]H-pyrrolo[2,3-...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

LigandPNGBDBM500828(7-[[6- (3,3a,4,5,6,6a- hexahydro- 2]H-pyrrolo[2,3-...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent

LigandPNGBDBM500828(7-[[6- (3,3a,4,5,6,6a- hexahydro- 2]H-pyrrolo[2,3-...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent