BDBM500829 7-[[5-[(2R)-2- [[cyclopropyl (methyl)amino] methyl]morph- olin-4-yl]-2- pyridyl]amino]- 4-(7-fluoroimidazo [1,2-a]pyridin- yl)isoindolin- 1-one::US11021481, Compound I-494::US11078201, Compound I-494::US11548890, Compound I-494

SMILES CN(C[C@@H]1CN(CCO1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)nc1)C1CC1

InChI Key InChIKey=MBFXHMMPIPWCEU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 500829   

LigandPNGBDBM500829(7-[[5-[(2R)-2- [[cyclopropyl (methyl)amino] methyl...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500829(7-[[5-[(2R)-2- [[cyclopropyl (methyl)amino] methyl...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500829(7-[[5-[(2R)-2- [[cyclopropyl (methyl)amino] methyl...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

LigandPNGBDBM500829(7-[[5-[(2R)-2- [[cyclopropyl (methyl)amino] methyl...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent

LigandPNGBDBM500829(7-[[5-[(2R)-2- [[cyclopropyl (methyl)amino] methyl...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent