BDBM50083227 1-{1-[1-(2-Chloro-phenyl)-ethyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one::CHEMBL146054

SMILES CC(N1CCC(CC1)n1c2ccccc2[nH]c1=O)c1ccccc1Cl

InChI Key InChIKey=ICPHYGRATJRGHH-UHFFFAOYSA-N

Data  5 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50083227   

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083227(1-{1-[1-(2-Chloro-phenyl)-ethyl]-piperidin-4-yl}-1...)
Affinity DataIC50: 5.90nMAssay Description:Binding affinity in CHO cells stably expressing cloned human Opioid receptor like 1 by displacing radioligand [125I]Tyr14-nociceptinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083227(1-{1-[1-(2-Chloro-phenyl)-ethyl]-piperidin-4-yl}-1...)
Affinity DataEC50:  25nMAssay Description:Agonistic activity against nociceptin produced GTPgammaS binding to Opioid receptor like 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50083227(1-{1-[1-(2-Chloro-phenyl)-ethyl]-piperidin-4-yl}-1...)
Affinity DataEC50:  31nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083227(1-{1-[1-(2-Chloro-phenyl)-ethyl]-piperidin-4-yl}-1...)
Affinity DataIC50: 32nMAssay Description:Binding affinity of the compound in CHO cells stably expressing cloned human Opioid receptor kappa 1 by displacing radioligand [3H]-U-69,593More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50083227(1-{1-[1-(2-Chloro-phenyl)-ethyl]-piperidin-4-yl}-1...)
Affinity DataIC50: 43nMAssay Description:Binding affinity in CHO cells stably expressing cloned human Opioid receptor mu 1 by displacing diprenorphineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50083227(1-{1-[1-(2-Chloro-phenyl)-ethyl]-piperidin-4-yl}-1...)
Affinity DataEC50:  199nMAssay Description:Agonist activity at human mu opioid receptor expressed in human USOS-beta-arrestin-hMOR-PathHunter cells incubated for 90 mins by beta-arrestin-2 enz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083227(1-{1-[1-(2-Chloro-phenyl)-ethyl]-piperidin-4-yl}-1...)
Affinity DataIC50: 1.90E+3nMAssay Description:Binding affinity in CHO cells stably expressing cloned human Opioid receptor delta 1 by displacing radioligand [3H][D-Ala2,D-Leu5]enkephalinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083227(1-{1-[1-(2-Chloro-phenyl)-ethyl]-piperidin-4-yl}-1...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonistic activity against nociceptin produced [35S]GTP-gamma-S, binding to Opioid receptor like 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed