BDBM50083643 (4-Pyridin-3-yl-pyrimidin-2-yl)-(3,4,5-trimethoxy-phenyl)-amine::CHEMBL112263

SMILES COc1cc(Nc2nccc(n2)-c2cccnc2)cc(OC)c1OC

InChI Key InChIKey=QJCXQYYKOKAXEK-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50083643   

TargetTyrosine-protein kinase Lck(Human)
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083643((4-Pyridin-3-yl-pyrimidin-2-yl)-(3,4,5-trimethoxy-...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of p56 lck tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50083643((4-Pyridin-3-yl-pyrimidin-2-yl)-(3,4,5-trimethoxy-...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of protein kinase C (PKC)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083643((4-Pyridin-3-yl-pyrimidin-2-yl)-(3,4,5-trimethoxy-...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of Zeta-chain (TCR) associated protein kinase 70 kDa phosphorylation of polyGly-Tyr.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase CSK(Human)
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083643((4-Pyridin-3-yl-pyrimidin-2-yl)-(3,4,5-trimethoxy-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of csk tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083643((4-Pyridin-3-yl-pyrimidin-2-yl)-(3,4,5-trimethoxy-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Epidermal growth factor receptor (EGFr)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed