BDBM50084248 CHEMBL124642::CHEMBL555571::N,N-Diethyl-4-[(4-methyl-piperazin-1-yl)-phenyl-methyl]-benzamide; hydrochloride

SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCN(C)CC1)c1ccccc1

InChI Key InChIKey=ADYWDZJRWKEHMW-UHFFFAOYSA-N

Data  3 KI  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50084248   

TargetDelta-type opioid receptor(Human)
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50084248(CHEMBL555571 | CHEMBL124642 | N,N-Diethyl-4-[(4-me...)
Affinity DataIC50: 40nMAssay Description:Binding affinity against human opioid receptor delta 1 using [125I]-[D-Ala2]-deltorphin II as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50084248(CHEMBL555571 | CHEMBL124642 | N,N-Diethyl-4-[(4-me...)
Affinity DataKi:  43nMAssay Description:In vitro binding affinity to Opioid receptor delta 1 in rat brain membranes by [3H]DADLE (Tyr-D-Ala-Gly-Phe-D-Leu) displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50084248(CHEMBL555571 | CHEMBL124642 | N,N-Diethyl-4-[(4-me...)
Affinity DataEC50:  211nMAssay Description:Agonist potency was measured using GTP gamma-[35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50084248(CHEMBL555571 | CHEMBL124642 | N,N-Diethyl-4-[(4-me...)
Affinity DataIC50: 6.97E+3nMAssay Description:Binding affinity against cloned human Opioid receptor kappa 1 using [125I]-D-Pro10-dynorphin A[1-11] as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50084248(CHEMBL555571 | CHEMBL124642 | N,N-Diethyl-4-[(4-me...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity against cloned human Opioid receptor mu 1 using [125I]FK33824 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50084248(CHEMBL555571 | CHEMBL124642 | N,N-Diethyl-4-[(4-me...)
Affinity DataKi:  1.00E+4nMAssay Description:In vitro radioligand binding assay, for inhibition of [3H]DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 in rat brain membrane...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50084248(CHEMBL555571 | CHEMBL124642 | N,N-Diethyl-4-[(4-me...)
Affinity DataKi:  1.00E+4nMAssay Description:In vitro radioligand binding assay, for inhibition of [3H]U-69593 binding to Opioid receptor kappa 1, in guinea pig brain membranes, at highest conce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2012
Entry Details Article
PubMed