BDBM50084464 CHEMBL3426891

SMILES CN1CCN(CC1)c2ccc(cc2)Nc3ncc(c(n3)NC[C@H]4CCCO4)Cl

InChI Key InChIKey=MMJSYUQCKWEFRW-UHFFFAOYSA-N

Data  11 IC50

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50084464   

TargetTyrosine-protein kinase JAK2(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50084464(CHEMBL3426891)
Affinity DataIC50: 6nMAssay Description:Inhibition of human JAK2 using poly[Glu:Tyr] (4:1) peptide substrate by 33P Hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50084464(CHEMBL3426891)
Affinity DataIC50: 5nMAssay Description:Inhibition of human TYK2 using KKSRGDYMTMQIG peptide substrate by 33P Hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50084464(CHEMBL3426891)
Affinity DataIC50: 160nMAssay Description:Inhibition of human FGFR1 using KKKSPGEYVNIEFG peptide substrate by 33P Hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50084464(CHEMBL3426891)
Affinity DataIC50: 206nMAssay Description:Inhibition of human ABL1 using EAIYAAPFAKKK peptide substrate by 33P Hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50084464(CHEMBL3426891)
Affinity DataIC50: 154nMAssay Description:Inhibition of human CHK1 using KKKVSRSGLYRSPSMPENLNRPR peptide substrate by 33P Hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50084464(CHEMBL3426891)
Affinity DataIC50: 143nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) peptide substrate by 33P Hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50084464(CHEMBL3426891)
Affinity DataIC50: 136nMAssay Description:Inhibition of human LCK using peptide poly[Glu:Tyr] (4:1) substrate by 33P Hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50084464(CHEMBL3426891)
Affinity DataIC50: 124nMAssay Description:Inhibition of human ROS/ROS1 using KKKSPGEYVNIEFG peptide substrate by 33P Hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50084464(CHEMBL3426891)
Affinity DataIC50: 438nMAssay Description:Inhibition of human c-Src using poly[Glu:Tyr] (4:1) peptide substrate by 33P Hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50084464(CHEMBL3426891)
Affinity DataIC50: 56nMAssay Description:Inhibition of ACK1 kinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetActivated CDC42 kinase 1(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50084464(CHEMBL3426891)
Affinity DataIC50: 58nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)