BDBM50085411 3-[1-(3,5-Dichloro-4-hydroxy-phenyl)-meth-(Z)-ylidene]-5-(furan-2-carbonyl)-1,3-dihydro-indol-2-one::CHEMBL73157::GSK screening, 31

SMILES Oc1c(Cl)cc(\C=C2/C(=O)Nc3ccc(cc23)C(=O)c2ccco2)cc1Cl

InChI Key InChIKey=XKTUKRBLWOHYIL-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50085411   

TargetSerine/threonine-protein kinase TBK1(Human)
Technical University of Dortmund

LigandPNGBDBM50085411(3-[1-(3,5-Dichloro-4-hydroxy-phenyl)-meth-(Z)-ylid...)
Affinity DataIC50: 282nMAssay Description:IC50 determinations for TBK1 were performed with the KinEASE-STK assay from Cisbio according to the manufacturer's instructions. A biotinylated s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2015
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Glaxo Wellcome

Curated by ChEMBL
LigandPNGBDBM50085411(3-[1-(3,5-Dichloro-4-hydroxy-phenyl)-meth-(Z)-ylid...)
Affinity DataIC50: 46nMAssay Description:Inhibition of cRaf1 kinase in cascade assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Glaxo Wellcome

Curated by ChEMBL
LigandPNGBDBM50085411(3-[1-(3,5-Dichloro-4-hydroxy-phenyl)-meth-(Z)-ylid...)
Affinity DataIC50: 46nMAssay Description:Inhibition of Raf1 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Glaxo Wellcome

Curated by ChEMBL
LigandPNGBDBM50085411(3-[1-(3,5-Dichloro-4-hydroxy-phenyl)-meth-(Z)-ylid...)
Affinity DataIC50: 40nMAssay Description:Inhibition of cRaf1 kinase in cascade assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetKinesin-like protein KIF15(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50085411(3-[1-(3,5-Dichloro-4-hydroxy-phenyl)-meth-(Z)-ylid...)
Affinity DataIC50: 750nMAssay Description:Inhibition of recombinant His6-tagged Kif15 (N700 residues) (unknown origin) expressed in HeLa cells assessed as reduction in Alexa-594 labelled micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKinesin-like protein KIF15(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50085411(3-[1-(3,5-Dichloro-4-hydroxy-phenyl)-meth-(Z)-ylid...)
Affinity DataIC50: 820nMAssay Description:Inhibition of recombinant His6-tagged Kif15 ATPase activity (N420 residues) (unknown origin) expressed in HeLa cells using microtubule as substrate p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK1(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50085411(3-[1-(3,5-Dichloro-4-hydroxy-phenyl)-meth-(Z)-ylid...)
Affinity DataIC50: 13nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ULK1(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50085411(3-[1-(3,5-Dichloro-4-hydroxy-phenyl)-meth-(Z)-ylid...)
Affinity DataIC50: 30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ULK1(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50085411(3-[1-(3,5-Dichloro-4-hydroxy-phenyl)-meth-(Z)-ylid...)
Affinity DataIC50: 427nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed