BDBM50085505 (1R,3S,5R)-5-(4-Chloro-phenyl)-3-p-tolyl-7-aza-tricyclo[5.3.0.0*4,8*]decan-5-ol::CHEMBL419728

SMILES Cc1ccc(cc1)[C@H]1C[C@H]2CCC3C1[C@](O)(CN23)c1ccc(Cl)cc1

InChI Key

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50085505   

TargetSodium-dependent serotonin transporter(Human)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50085505((1R,3S,5R)-5-(4-Chloro-phenyl)-3-p-tolyl-7-aza-tri...)
Affinity DataIC50: 13nMAssay Description:The compound was tested for inhibition of [3H]-5-hydroxy tryptamine uptake in HEK cells by expressing cDNA for human tryptamine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50085505((1R,3S,5R)-5-(4-Chloro-phenyl)-3-p-tolyl-7-aza-tri...)
Affinity DataIC50: 23nMAssay Description:The compound was tested for inhibition of [3H]norepinephrine uptake in HEK cells by expressing cDNA for human norepinephrine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50085505((1R,3S,5R)-5-(4-Chloro-phenyl)-3-p-tolyl-7-aza-tri...)
Affinity DataIC50: 44nMAssay Description:Inhibition of [3H]dopamine uptake in HEK cells expressing human Dopamine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed