BDBM50085596 CHEMBL3425536

SMILES Cc1nc2ccncc2n2c(nnc12)-c1cc(OC(F)(F)F)ccc1Cl

InChI Key InChIKey=LKBVNJHZZJQSPX-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50085596   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica

Curated by ChEMBL

LigandBDBM50085596(CHEMBL3425536)Copy SMILESCopy InChI

Affinity DataIC50: 150nMAssay Description:Inhibition of 6-His-tagged human recombinant PDE2A expressed in Sf9 cells using [3H]cGMP incubated for 40 mins by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
5/5/2016
Entry Details Article
Copy BDB DOIPubMed
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TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rat)
Janssen Pharmaceutica

Curated by ChEMBL

LigandBDBM50085596(CHEMBL3425536)Copy SMILESCopy InChI

Affinity DataIC50: 8.91E+3nMAssay Description:Inhibition of 6-His-tagged rat recombinant PDE10A expressed in Sf9 cells using [3H]cAMP incubated for 60 mins by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
5/5/2016
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL