BDBM500859 4-(7- fluoroimidazo [1,2-a]pyridin- 3-yl)-7-((5- ((R)-1-((S)-2- methylmorpho- lino)ethyl)pyr- idin-2-yl)amino) isoin-dolin-1-one::US11021481, Compound I-523::US11078201, Compound I-523::US11548890, Compound I-523

SMILES C[C@@H](N1CCO[C@@H](C)C1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)nc1

InChI Key InChIKey=MKMKTMMJTCLKIA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 500859   

LigandPNGBDBM500859(4-(7- fluoroimidazo [1,2-a]pyridin- 3-yl)-7-((5- (...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500859(4-(7- fluoroimidazo [1,2-a]pyridin- 3-yl)-7-((5- (...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500859(4-(7- fluoroimidazo [1,2-a]pyridin- 3-yl)-7-((5- (...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

LigandPNGBDBM500859(4-(7- fluoroimidazo [1,2-a]pyridin- 3-yl)-7-((5- (...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

LigandPNGBDBM500859(4-(7- fluoroimidazo [1,2-a]pyridin- 3-yl)-7-((5- (...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent