BDBM50086537 2,2,4-Trimethyl-6-(5-nitro-thiophen-2-yl)-1,2-dihydro-quinoline::2,2,4-trimethyl-6-(5-nitrothiophen-2-yl)-1,2-dihydroquinoline::CHEMBL133656

SMILES CC1=CC(C)(C)Nc2ccc(cc12)-c1ccc(s1)[N+]([O-])=O

InChI Key InChIKey=DCFLRZWZJAAAGE-UHFFFAOYSA-N

Data  2 KI  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50086537   

TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086537(2,2,4-Trimethyl-6-(5-nitro-thiophen-2-yl)-1,2-dihy...)
Affinity DataKi:  2.60nMAssay Description:Binding affinity against human progesterone receptor (hPR) in a competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086537(2,2,4-Trimethyl-6-(5-nitro-thiophen-2-yl)-1,2-dihy...)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]progesterone from Progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086537(2,2,4-Trimethyl-6-(5-nitro-thiophen-2-yl)-1,2-dihy...)
Affinity DataIC50: 31nMAssay Description:Antagonist activity against human progesterone receptor (hPR) using cotransfection assay in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086537(2,2,4-Trimethyl-6-(5-nitro-thiophen-2-yl)-1,2-dihy...)
Affinity DataIC50: 70nMAssay Description:Antagonist activity against human progesterone receptor (hPR) in T47D human breast cancer cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086537(2,2,4-Trimethyl-6-(5-nitro-thiophen-2-yl)-1,2-dihy...)
Affinity DataEC50:  1.02E+3nMAssay Description:Human progesterone receptor (hPR) agonist activity in T47D human breast cancer cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086537(2,2,4-Trimethyl-6-(5-nitro-thiophen-2-yl)-1,2-dihy...)
Affinity DataIC50: 1.46E+3nMAssay Description:Cross-reactivity as binding to human androgen receptor (hAR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed