BDBM50086604 CHEMBL3426308

SMILES C[C@@]12Cc3[nH]nc(C(=O)Nc4cnn([C@H](c5ccccc5)C5CCS(=O)(=O)CC5)c4)c3C[C@@H]1C2

InChI Key InChIKey=SDZFNFGEAWBFTM-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50086604   

TargetTyrosine-protein kinase ITK/TSK(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50086604BDBM50086604(CHEMBL3426308)
Affinity DataKi:  0.200nMAssay Description:Inhibition of GST-tagged recombinant full length human ITK using AcEFPIYDFLPAKKK-NH2 as substrate after 35 mins by Morrison plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50086604BDBM50086604(CHEMBL3426308)
Affinity DataIC50: 39nMAssay Description:Inhibition of ITK in TCR stimulated human Jurkat T cells assessed as reduction of PLC-gamma phosphorylation preincubated for 30 mins followed by TCR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50086604BDBM50086604(CHEMBL3426308)
Affinity DataKi:  260nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed