BDBM50087019 8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one::CHEMBL418020

SMILES Clc1ccc(Cl)c2C[C@@H](CCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1

InChI Key InChIKey=GKBLBGBXCLKVGY-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50087019   

TargetMu-type opioid receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50087019(8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Affinity DataKi:  8.40nMAssay Description:Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor mu 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50087019(8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Affinity DataKi:  21nMAssay Description:Effective concentration required to stimulate binding of GTPgammaS to Opioid receptor like 1 was determined using scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50087019(8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Affinity DataKi:  47nMAssay Description:Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50087019(8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Affinity DataKi:  587nMAssay Description:Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor delta 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed