BDBM50088537 CHEMBL6251::US10189805, Compound 1

SMILES N[C@@H](CCC(=O)Nc1ccc(cc1)[N+]([O-])=O)C(O)=O

InChI Key InChIKey=WMZTYIRRBCGARG-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50088537   

TargetNeutral amino acid transporter B(0)(Human)
Vanderbilt University Institute of Imaging Science (Vuiis)

Curated by ChEMBL
LigandPNGBDBM50088537(CHEMBL6251 | US10189805, Compound 1)
Affinity DataIC50: 9.54E+5nMAssay Description:Inhibition of ASCT2-mediated [3H]glutamine uptake in HEK293 cells after 15 mins by Live-cell glutamine uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2016
Entry Details Article
PubMed
TargetNeutral amino acid transporter B(0)(Human)
Vanderbilt University Institute of Imaging Science (Vuiis)

Curated by ChEMBL
LigandPNGBDBM50088537(CHEMBL6251 | US10189805, Compound 1)
Affinity DataIC50: 1.20E+6nMAssay Description:Inhibition of ASCT2-mediated glutamine transport in human HEK293 cells using [3H]-glutamine after 15 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2017
Entry Details Article
PubMed
TargetAmino acid transporter(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50088537(CHEMBL6251 | US10189805, Compound 1)
Affinity DataIC50: 7.02E+4nMAssay Description:Inhibition of ASCT2-mediated glutamine transport in rat C6 cells using [3H]-glutamine after 15 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2017
Entry Details Article
PubMed
TargetNeutral amino acid transporter B(0)(Human)
Vanderbilt University Institute of Imaging Science (Vuiis)

Curated by ChEMBL
LigandPNGBDBM50088537(CHEMBL6251 | US10189805, Compound 1)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of ASCT2 (unknown origin)-mediated glutamine transportMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2017
Entry Details Article
PubMed
TargetNeutral amino acid transporter B(0)(Human)
Vanderbilt University Institute of Imaging Science (Vuiis)

Curated by ChEMBL
LigandPNGBDBM50088537(CHEMBL6251 | US10189805, Compound 1)
Affinity DataIC50: 9.54E+5nMAssay Description:The glutamine uptake assays in HEK293 cells were carried out in 96 well plates (CulturPlate-96, Perkin Elmer). Cells were plated at a density of 35,0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
Go to US Patent

TargetNeutral amino acid transporter B(0)(Human)
Vanderbilt University Institute of Imaging Science (Vuiis)

Curated by ChEMBL
LigandPNGBDBM50088537(CHEMBL6251 | US10189805, Compound 1)
Affinity DataIC50: 1.20E+6nMAssay Description:Inhibition of ASCT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed