BDBM50090895 (2R,3R,4S,5R)-2-[4-(4-Fluoro-phenylamino)-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl]-5-methyl-tetrahydro-furan-3,4-diol::(2S,3S,4R,5S)-2-[4-(4-Fluoro-phenylamino)-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl]-5-methyl-tetrahydro-furan-3,4-diol::2-[4-(4-Fluoro-phenylamino)-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl]-5-methyl-tetrahydro-furan-3,4-diol::4-(4-fluorophenylamino)-5-phenyl-7-(5-deoxy-beta-D-ribofuranosyl)-pyrrolo[2,3-d]pyrimidine::CHEMBL66277

SMILES C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(-c2ccccc2)c2c(Nc3ccc(F)cc3)ncnc12

InChI Key InChIKey=MULTXXBUCOCYME-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50090895   

TargetAdenosine kinase(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50090895(2-[4-(4-Fluoro-phenylamino)-5-phenyl-pyrrolo[2,3-d...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of recombinant human adenosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine kinase(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50090895(2-[4-(4-Fluoro-phenylamino)-5-phenyl-pyrrolo[2,3-d...)
Affinity DataIC50: 134nMAssay Description:Inhibition of adenosine phosphorylation in confluent IMR-32 (human neuroblastoma) cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine kinase(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50090895(2-[4-(4-Fluoro-phenylamino)-5-phenyl-pyrrolo[2,3-d...)
Affinity DataIC50: 2.80nMAssay Description:In vitro inhibition of Adenosine kinase (AK)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine kinase(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50090895(2-[4-(4-Fluoro-phenylamino)-5-phenyl-pyrrolo[2,3-d...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against human recombinant adenosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine kinase(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50090895(2-[4-(4-Fluoro-phenylamino)-5-phenyl-pyrrolo[2,3-d...)
Affinity DataIC50: 1.5nMAssay Description:Inhibitory activity against recombinant human adenosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine kinase(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50090895(2-[4-(4-Fluoro-phenylamino)-5-phenyl-pyrrolo[2,3-d...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human adenosine kinase assessed as reduction in conversion of adenosine to AMPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed