BDBM50091743 (S)-2-Benzenesulfonylamino-3-[2-(1-oxo-7-piperazin-1-yl-3,4-dihydro-1H-isoquinolin-2-yl)-acetylamino]-propionic acid::CHEMBL57134

SMILES OC(=O)[C@H](CNC(=O)CN1CCc2ccc(cc2C1=O)N1CCNCC1)NS(=O)(=O)c1ccccc1

InChI Key InChIKey=CSICLXCUTLXRPU-UHFFFAOYSA-N

Data  1 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50091743   

TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50091743((S)-2-Benzenesulfonylamino-3-[2-(1-oxo-7-piperazin...)
Affinity DataKd:  13nMAssay Description:Binding affinity to resting form of alpha IIb/beta3 integrin by flow cytometry using fluorescein ligand L-726,745 displacement from human platelets.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50091743((S)-2-Benzenesulfonylamino-3-[2-(1-oxo-7-piperazin...)
Affinity DataIC50: 35nMAssay Description:Inhibition of aggregation of human gel-filtered platelets measured by light transmittance method at 37 degrees C.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50091743((S)-2-Benzenesulfonylamino-3-[2-(1-oxo-7-piperazin...)
Affinity DataKd:  6.70nMAssay Description:Competition with [1251]L-692,884 for binding to purified alpha IIb/beta3 integrin, activated by coating onto yttrium silicate scintillation proximity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed