BDBM50092046 3-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1-ethyl-3,4-dihydro-1H-quinolin-2-one::CHEMBL68191

SMILES CCN1C(=O)C(Cc2ccccc12)N1CCN(Cc2ccc(Cl)cc2)CC1

InChI Key InChIKey=BZWQAKCTTBOIKJ-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50092046   

TargetD(4) dopamine receptor(Human)
Neurogen

Curated by ChEMBL
LigandPNGBDBM50092046(3-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1-ethyl-3,4...)
Affinity DataKi:  4nMAssay Description:Binding affinity at human Dopamine receptor D4 by [3H]- YM 09151 displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Neurogen

Curated by ChEMBL
LigandPNGBDBM50092046(3-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1-ethyl-3,4...)
Affinity DataKi:  4nMAssay Description:D4 receptor functional activity was measured inhibition of quinpirole stimulated [35S]GTP-gamma-S binding from cell membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Neurogen

Curated by ChEMBL
LigandPNGBDBM50092046(3-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1-ethyl-3,4...)
Affinity DataKi:  21nMAssay Description:Binding affinity at human Dopamine receptor D2 by [3H]- YM 09151 displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Neurogen

Curated by ChEMBL
LigandPNGBDBM50092046(3-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1-ethyl-3,4...)
Affinity DataKi:  21nMAssay Description:D2 receptor functional activity was measured through reversal of quinpirole inhibited, forskolin stimulated cAMP production from whole cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50092046(3-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1-ethyl-3,4...)
Affinity DataKi:  1.27E+3nMAssay Description:Displacement of [3H]prazosin from alpha-1 adrenergic receptor of rat brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed