BDBM50092206 CHEMBL3581276

SMILES [H][C@@]12CCCN1C(=O)[C@H](Cc1ccc3ccccc3c1)NC(=O)[C@H](CCCNC(N)=N)N(C)C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc1ccc(O)cc1)NC2=O

InChI Key InChIKey=LTTCRTAQQFHLPF-UHFFFAOYSA-N

Data  4 IC50  12 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50092206   

TargetAtypical chemokine receptor 3(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50092206(CHEMBL3581276)
Affinity DataEC50:  91nMAssay Description:Activation of YFP-tagged ACKR3 (unknown origin) expressed in HEK293E cells assessed as induction of Rluc-tagged beta-arrestin-2 recruitment after 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2020
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50092206(CHEMBL3581276)
Affinity DataEC50:  95nMAssay Description:Agonist activity at CXCR7 (unknown origin) expressed in HEK293E cells co-transfected with receptor-eYFP construct and beta-arrestin2-Rluc assessed as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50092206(CHEMBL3581276)
Affinity DataEC50:  100nMAssay Description:Activation of YFP-tagged ACKR3 (unknown origin) expressed in HEK293E cells assessed as induction of Rluc-tagged beta-arrestin-2 recruitment after 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2020
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50092206(CHEMBL3581276)
Affinity DataEC50:  100nMAssay Description:Agonist activity at CXCR7 (unknown origin) expressed in HEK293E cells co-transfected with receptor-eYFP construct and beta-arrestin2-Rluc assessed as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50092206(CHEMBL3581276)
Affinity DataEC50:  240nMAssay Description:Agonist activity at wild type CXCR7 (unknown origin) expressed in HEK293E cells co-transfected with receptor-eYFP construct and beta-arrestin2-Rluc a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50092206(CHEMBL3581276)
Affinity DataEC50:  240nMAssay Description:Agonist activity at wild type CXCR7 (unknown origin) expressed in HEK293E cells co-transfected with receptor-eYFP construct and beta-arrestin2-Rluc a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50092206(CHEMBL3581276)
Affinity DataEC50:  360nMAssay Description:Agonist activity at CXCR7 S198R mutant (unknown origin) expressed in HEK293E cells co-transfected with receptor-eYFP construct and beta-arrestin2-Rlu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50092206(CHEMBL3581276)
Affinity DataEC50:  360nMAssay Description:Agonist activity at CXCR7 S198R mutant (unknown origin) expressed in HEK293E cells co-transfected with receptor-eYFP construct and beta-arrestin2-Rlu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50092206(CHEMBL3581276)
Affinity DataEC50:  631nMAssay Description:Agonist activity at CXCR7 D275N mutant (unknown origin) expressed in HEK293E cells co-transfected with receptor-eYFP construct and beta-arrestin2-Rlu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50092206(CHEMBL3581276)
Affinity DataEC50:  650nMAssay Description:Agonist activity at CXCR7 D275N mutant (unknown origin) expressed in HEK293E cells co-transfected with receptor-eYFP construct and beta-arrestin2-Rlu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50092206(CHEMBL3581276)
Affinity DataIC50: 800nMAssay Description:Inhibition of [125I]SDF-1alpha binding to CXCR7 (unknown origin) expressed in CHO cell membranes incubated for 1 hr by radioligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50092206(CHEMBL3581276)
Affinity DataIC50: 860nMAssay Description:Displacement of [125I]SDF-1alpha from ACKR3 (unknown origin) expressed in CHO cells after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2020
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50092206(CHEMBL3581276)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonist activity at CXCR7 D179N mutant (unknown origin) expressed in HEK293E cells co-transfected with receptor-eYFP construct and beta-arrestin2-Rlu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50092206(CHEMBL3581276)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonist activity at CXCR7 D179N mutant (unknown origin) expressed in HEK293E cells co-transfected with receptor-eYFP construct and beta-arrestin2-Rlu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50092206(CHEMBL3581276)
Affinity DataIC50: 3.00E+4nMAssay Description:Displacement of [125I]SDF-1alpha from CXCR4 (unknown origin) expressed in HEK293 cells after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2020
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50092206(CHEMBL3581276)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of [125I]SDF-1alpha binding to CXCR4 (unknown origin) expressed in HEK293 cell membranes incubated for 1 hr by radioligand displacement as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details Article
PubMed