BDBM50093539 7,8-Dihydroxy-2-phenyl-chromen-4-one::7,8-Dihydroxyflavone::7,8-dihydroxy-2-phenyl-4H-chromen-4-one::CHEMBL75267

SMILES c1ccc(cc1)C2=CC(=O)c3ccc(c(c3O2)O)O

InChI Key InChIKey=COCYGNDCWFKTMF-UHFFFAOYSA-N

Data  5 IC50  2 Kd

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50093539   

TargetTyrosine-protein kinase Lck(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50093539(7,8-dihydroxy-2-phenyl-4H-chromen-4-one | 7,8-Dihy...)
Affinity DataIC50: 3.14E+5nMAssay Description:Inhibition of p56 lckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetTelomerase reverse transcriptase(Human)
Bu-Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50093539(7,8-dihydroxy-2-phenyl-4H-chromen-4-one | 7,8-Dihy...)
Affinity DataIC50: 3.60E+4nMAssay Description:Inhibition of human telomerase from HEK293 cell extracts by Flash-Plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50093539(7,8-dihydroxy-2-phenyl-4H-chromen-4-one | 7,8-Dihy...)
Affinity DataIC50: 9.82E+3nMAssay Description:Inhibition of IKK-beta using TMB substrate after 15 mins by spectrophotometer analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50093539(7,8-dihydroxy-2-phenyl-4H-chromen-4-one | 7,8-Dihy...)
Affinity DataKd:  320nMAssay Description:Binding affinity to TrkB receptor extracellular domain (unknown origin) after 10 mins by liquid Scatchard plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))TBA
LigandPNGBDBM50093539(7,8-dihydroxy-2-phenyl-4H-chromen-4-one | 7,8-Dihy...)
Affinity DataIC50: 3.50E+5nMAssay Description:In vitro antibacterial activity was determined as inhibitory concentration causing 50% DNA-gyrase supercoiling inhibition (SCI)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2018
Entry Details

TargetBDNF/NT-3 growth factors receptor(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50093539(7,8-dihydroxy-2-phenyl-4H-chromen-4-one | 7,8-Dihy...)
Affinity DataKd:  10nMAssay Description:Binding affinity to recombinant human TrkB receptor ECD assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetArginase(Leishmania amazonensis)
Birla Institute of Technology and Science Pilani

Curated by ChEMBL
LigandPNGBDBM50093539(7,8-dihydroxy-2-phenyl-4H-chromen-4-one | 7,8-Dihy...)
Affinity DataIC50: 1.20E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed