BDBM50094313 CHEMBL3590109

SMILES C=CS(=O)(=O)N1CCc2cnc(NC3CCOCC3)nc2C1

InChI Key InChIKey=URRXSHLGWLQOEC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50094313   

TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094313(CHEMBL3590109)
Affinity DataIC50: 220nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094313(CHEMBL3590109)
Affinity DataIC50: 240nMAssay Description:Inhibition of ERK2 in human A375 cells harboring B-RAF V600E mutant assessed as decrease in phospho-ERK2 level after 2 hrs by Cellomics ArrayScanTM V...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094313(CHEMBL3590109)
Affinity DataIC50: 370nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
LigandPNGBDBM50094313(CHEMBL3590109)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of MEK1 (unknown origin) autophosphorylation incubated with enzyme for 20 mins prior to ATP addition by ADP Glo kinase assay in presence o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed