BDBM50094478 CHEMBL3590224

SMILES CN(C)CC(=O)N1CCC(CC1)c1cn(C)c(n1)-c1cnc(N)c(n1)-n1nnc2ccccc12

InChI Key InChIKey=KUUZBILDRYMEAQ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50094478   

LigandPNGBDBM50094478(CHEMBL3590224)
Affinity DataIC50: 64nMAssay Description:Inhibition of recombinant human PI3Kalpha using PIP2/ATP as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
LigandPNGBDBM50094478(CHEMBL3590224)
Affinity DataIC50: 690nMAssay Description:Inhibition of PI3Kalpha in human BT474 cells assessed as inhibition of Akt phosphorylation at Tyr-308 after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50094478(CHEMBL3590224)
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
LigandPNGBDBM50094478(CHEMBL3590224)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of recombinant human PI3Kbeta using PIP2/ATP as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
LigandPNGBDBM50094478(CHEMBL3590224)
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of PI3Kbeta in human MDA-MB-468 cells assessed as inhibition of Akt phosphorylation at Ser-473 after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed